Hamilton Ion-Exclusion HPLC Columns

Hamilton Ion-Exclusion HPLC Columns

Ion-exclusion chromatography columns (Ion Exclusion Columns)

Hamilton PRP-X300 ion-exclusion HPLC columns

The PRP-X300 is a versatile, high-performance ion-exclusion column developed for the rapid separation of structurally similar organic acids and alcohols.

The column operates through a combination of separation mechanisms:

• ion exclusion
• hydrogen bonding
• reversed-phase interactions

As a result, the PRP-X300 can also be used effectively for samples that would show excessive retention on conventional ion-exclusion media.

Key features and benefits

• Polymer-based PS-DVB/sulfonic acid packing with excellent chemical stability
• Isocratic separation with narrow, well-defined peaks
• Selectivity can be finely controlled by adjusting the pH or adding organic modifiers (e.g. methanol or acetonitrile)
• Resistant to organic solvents, allowing a wider range of sample matrices to be handled

Configurations and available formats

PRP-X300 columns are available:

• in stainless-steel and PEEK configurations
• in various column lengths and diameters
• in analytical and semi-preparative dimensions
• with guard columns and guard cartridge systems
• as bulk resin for method development

Extensive range – catalogue-based search

Ion-exclusion HPLC columns are available in numerous dimensions, particle sizes and configurations, so the complete range is not listed individually on this page.